Cognitive impairment and its neuroimaging correlates in spinocerebellar ataxia 2.

ABSTRACT:

Introduction

Cognitive impairment (CI) is reported but is poorly explored in spinocerebellar ataxia 2 (SCA2). This study was undertaken to evaluate and classify cognitive impairment in patients with SCA2 and to identify their grey matter (GM) correlates.

Methods

We evaluated the neurocognitive profile of 35 SCA2 and 30 age-, gender- and education-matched healthy controls using tests for attention, executive functions, learning and memory, language and fluency, and visuomotor constructive ability. Patients were classified into SCA2 with and without CI based on normative data from population and healthy controls. Furthermore, patients with CI were sub-classified based on the number of impaired domains into multi-domain CI (≥3 domains; MDCI) and limited domain CI (≤2 domains; L

SUBMITTER: Stezin A 

PROVIDER: S-EPMC7613150 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature