Morphometric mapping of the macrostructural abnormalities of midsagittal corpus callosum in Wilson's disease.

ABSTRACT:

Background and purpose

The corpus callosum (CC) consists of topographically arranged white matter (WM) fibers. Previous studies have indicated the CC to be discretely involved in WD. In this study, we strived to characterize the macrostructural properties of the CC using midsagittal cross-sectional area and thickness profile measurements.

Materials and methods

This study was performed using archived magnetic resonance imaging (MRI) scans of 14 patients with WD and 14 age- and gender-matched healthy controls. Using an automated software pipeline for morphometric profiling, the midsagittal CC was segmented into five sub-regions (CC_1-5) according to the Hofer-Frahm scheme. The mean thickness and area of different CC segments and their clinical and cognitive correlate

SUBMITTER: Stezin A 

PROVIDER: S-EPMC7613241 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature