Poor Bone Quality is Associated With Greater Arterial Stiffness: Insights From the UK Biobank.

ABSTRACT: Osteoporosis and ischemic heart disease (IHD) represent important public health problems. Existing research suggests an association between the two conditions beyond that attributable to shared risk factors, with a potentially causal relationship. In this study, we tested the association of bone speed of sound (SOS) from quantitative heel ultrasound with (i) measures of arterial compliance from cardiovascular magnetic resonance (aortic distensibility [AD]); (ii) finger photoplethysmography (arterial stiffness index [ASI]); and (iii) incident myocardial infarction and IHD mortality in the UK Biobank cohort. We considered the potential mediating effect of a range of blood biomarkers and cardiometabolic morbidities and evaluated differential relationships by sex, menopause status, smoking, di

SUBMITTER: Raisi-Estabragh Z 

PROVIDER: S-EPMC7613252 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature