Dataset Information

Global Burden of Childhood Epilepsy, Intellectual Disability, and Sensory Impairments.

ABSTRACT: Estimates of children and adolescents with disabilities worldwide are needed to inform global intervention under the disability-inclusive provisions of the Sustainable Development Goals. We sought to update the most widely reported estimate of 93 million children <15 years with disabilities from the Global Burden of Disease Study 2004. We analyzed Global Burden of Disease Study 2017 data on the prevalence of childhood epilepsy, intellectual disability, and vision or hearing loss and on years lived with disability (YLD) derived from systematic reviews, health surveys, hospital and claims databases, cohort studies, and disease-specific registries. Point estimates of the prevalence and YLD and the 95% uncertainty intervals (UIs) around the estimates were assessed. Globally, 291.2 million (11.2%) of the 2.6 billion children and adolescents (95% UI: 249.9-335.4 million) were estimated to have 1 of the 4 specified disabilities in 2017. The prevalence of these disabilities increased with age from 6.1% among children aged <1 year to 13.9% among adolescents aged 15 to 19 years. A total of 275.2 million (94.5%) lived in low- and middle-income countries, predominantly in South Asia and sub-Saharan Africa. The top 10 countries accounted for 62.3% of all children and adolescents with disabilities. These disabilities accounted for 28.9 million YLD or 19.9% of the overall 145.3 million (95% UI: 106.9-189.7) YLD from all causes among children and adolescents. The number of children and adolescents with these 4 disabilities is far higher than the 2004 estimate, increases from infancy to adolescence, and accounts for a substantial proportion of all-cause YLD.

SUBMITTER: Olusanya BO

PROVIDER: S-EPMC7613313 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Global Burden of Childhood Epilepsy, Intellectual Disability, and Sensory Impairments.

Olusanya Bolajoko O BO Wright Scott M SM Nair M K C MKC Boo Nem-Yun NY Halpern Ricardo R Kuper Hannah H Abubakar Amina A AA Almasri Nihad A NA Arabloo Jalal J Arora Narendra K NK Backhaus Sophia S Berman Brad D BD Breinbauer Cecilia C Carr Gwen G de Vries Petrus J PJ Del Castillo-Hegyi Christie C Eftekhari Aziz A Gladstone Melissa J MJ Hoekstra Rosa A RA Kancherla Vijaya V Mulaudzi Mphelekedzeni C MC Kakooza-Mwesige Angelina A Ogbo Felix A FA Olsen Helen E HE Olusanya Jacob O JO Pandey Ashok A Samms-Vaughan Maureen E ME Servili Chiara C Shaheen Amira A Smythe Tracey T Wertlieb Donald D Williams Andrew N AN Newton Charles R J CRJ Davis Adrian C AC Kassebaum Nicholas J NJ

Pediatrics 20200617 1

<h4>Background</h4>Estimates of children and adolescents with disabilities worldwide are needed to inform global intervention under the disability-inclusive provisions of the Sustainable Development Goals. We sought to update the most widely reported estimate of 93 million children <15 years with disabilities from the Global Burden of Disease Study 2004.<h4>Methods</h4>We analyzed Global Burden of Disease Study 2017 data on the prevalence of childhood epilepsy, intellectual disability, and visio ...[more]

PMID: 32554521

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Project description:BackgroundEpilepsy is genetically complex but common brain disorder of the world affecting millions of people with almost of all age groups. Novel Copy number variations (CNVs) are considered as important reason for the numerous neurodevelopmental disorders along with intellectual disability and epilepsy. DNA array based studies contribute to explain a more severe clinical presentation of the disease but interoperation of many detected CNVs are still challenging.ResultsIn order to study novel CNVs with epilepsy related genes in Saudi family with six affected and two normal individuals with several forms of epileptic seizures, intellectual disability (ID), and minor dysmorphism, we performed the high density whole genome Agilent sure print G3 Hmn CGH 2x 400 K array-CGH chips analysis. Our results showed de novo deletions, duplications and deletion plus duplication on differential chromosomal regions in the affected individuals that were not shown in the normal fathe and normal kids by using Agilent CytoGenomics 3.0.6.6 softwear. Copy number gain were observed in the chromosome 1, 16 and 22 with LCE3C, HPR, GSTT2, GSTTP2, DDT and DDTL genes respectively whereas the deletions observed in the chromosomal regions 8p23-p21 (4303127-4337759) and the potential gene in this region is CSMD1 (OMIM: 612279). Moreover, the array CGH results deletions and duplication were also validated by using primer design of deleted regions utilizing the flanked SNPs using simple PCR and also by using quantitative real time PCR.ConclusionsWe found some of the de novo deletions and duplication in our study in Saudi family with intellectual disability and epilepsy. Our results suggest that array-CGH should be used as a first line of genetic test for epilepsy except there is a strong indication for a monogenic syndrome. The advanced high through put array-CGH technique used in this study aim to collect the data base and to identify new mechanisms describing epileptic disorder, may help to improve the clinical management of individual cases in decreasing the burden of epilepsy in Saudi Arabia.

Dataset Information

Global Burden of Childhood Epilepsy, Intellectual Disability, and Sensory Impairments.

Publications

Global Burden of Childhood Epilepsy, Intellectual Disability, and Sensory Impairments.

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