Cell origin and niche availability dictate the capacity of peritoneal macrophages to colonize the cavity and omentum.

ABSTRACT: The relationship between macrophages of the peritoneal cavity and the adjacent omentum remains poorly understood. Here, we describe two populations of omental macrophages distinguished by CD102 expression and use an adoptive cell transfer approach to investigate whether these arise from peritoneal macrophages, and whether this depends upon inflammatory status, the origin of peritoneal macrophages and availability of the omental niches. We show that whereas established resident peritoneal macrophages largely fail to migrate to the omentum, monocyte-derived resident cells readily migrate and form a substantial component of omental CD102⁺ macrophages in the months following resolution of peritoneal inflammation. In contrast, both populations had the capacity to migrate to the oment

SUBMITTER: Louwe PA 

PROVIDER: S-EPMC7613338 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature