Validating pore size estimates in a complex microfiber environment on a human MRI system.

ABSTRACT:

Purpose

Recent advances in diffusion-weighted MRI provide "restricted diffusion signal fraction" and restricting pore size estimates. Materials based on co-electrospun oriented hollow cylinders have been introduced to provide validation for such methods. This study extends this work, exploring accuracy and repeatability using an extended acquisition on a 300 mT/m gradient human MRI scanner, in substrates closely mimicking tissue, that is, non-circular cross-sections, intra-voxel fiber crossing, intra-voxel distributions of pore-sizes, and smaller pore-sizes overall.

Methods

In a single-blind experiment, diffusion-weighted data were collected from a biomimetic phantom on a 3T Connectom system using multiple gradient directions/diffusion times. Repeated scans established short

SUBMITTER: Huang CC 

PROVIDER: S-EPMC7613441 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature