Incidence and patterns of abnormal corpus callosum in fetuses with isolated spina bifida aperta.

ABSTRACT:

Objective

To determine the incidence and characterise corpus callosum (CC) abnormalities in fetuses with spina bifida aperta (SBA) between 18 and 26 weeks of gestation.

Methods

This was a retrospective study on fetuses with isolated SBA and who were assessed for fetal surgery. Digitally stored ultrasound images of the brain were reviewed for the presence/absence of the CC, and the length and diameter of its constituent parts (rostrum, genu, body and splenium). We used regression analysis to determine the relationship between CC abnormalities and gestational age, head circumference, ventricle size, lesion level and lesion type.

Results

Nearly three-quarters of fetuses with isolated SBA had an abnormal CC (71.7%, 76/106). Partial agenesis was most common in the splenium

SUBMITTER: Kunpalin Y 

PROVIDER: S-EPMC7613455 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature