Shared genetic susceptibility between trigger finger and carpal tunnel syndrome: a genome-wide association study.

ABSTRACT:

Background

Trigger finger and carpal tunnel syndrome are the two most common non-traumatic connective tissue disorders of the hand. Both of these conditions frequently co-occur, often in patients with rheumatoid arthritis. However, this phenotypic association is poorly understood. Hypothesising that the co-occurrence of trigger finger and carpal tunnel syndrome might be explained by shared germline predisposition, we aimed to identify a specific genetic locus associated with both diseases.

Methods

In this genome-wide association study (GWAS), we identified 2908 patients with trigger finger and 436579 controls from the UK Biobank prospective cohort. We conducted a case-control GWAS for trigger finger, followed by co-localisation analyses with carpal tunnel syndrome summary st

SUBMITTER: Patel B 

PROVIDER: S-EPMC7613465 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature