ScipionTomo: Towards cryo-electron tomography software integration, reproducibility, and validation.

ABSTRACT: Image processing in cryogenic electron tomography (cryoET) is currently at a similar state as Single Particle Analysis (SPA) in cryogenic electron microscopy (cryoEM) was a few years ago. Its data processing workflows are far from being well defined and the user experience is still not smooth. Moreover, file formats of different software packages and their associated metadata are not standardized, mainly since different packages are developed by different groups, focusing on different steps of the data processing pipeline. The Scipion framework, originally developed for SPA (de la Rosa-Trevín et al., 2016), has a generic python workflow engine that gives it the versatility to be extended to other fields, as demonstrated for model building (Martínez et al., 2020). In this article, we provid

SUBMITTER: Jimenez de la Morena J 

PROVIDER: S-EPMC7613607 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature