Circadian asthma airway responses are gated by REV-ERBα.

ABSTRACT:

Background

The circadian clock powerfully regulates inflammation and the clock protein REV-ERBα is known to play a key role as a repressor of the inflammatory response. Asthma is an inflammatory disease of the airways with a strong time of day rhythm. Airway hyper-responsiveness (AHR) is a dominant feature of asthma; however, it is not known if this is under clock control.

Objectives

To determine if allergy-mediated AHR is gated by the clock protein REV-ERBα.

Methods

After exposure to the intra-nasal house dust mite (HDM) allergen challenge model at either dawn or dusk, AHR to methacholine was measured invasively in mice.

Main results

Wild-type (WT) mice show markedly different time of day AHR responses (maximal at dusk/start of the active phase), both in vi

SUBMITTER: Durrington HJ 

PROVIDER: S-EPMC7613655 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature