Rhythmicity of intestinal IgA responses confers oscillatory commensal microbiota mutualism.

ABSTRACT: Interactions between the mammalian host and commensal microbiota are enforced through a range of immune responses that confer metabolic benefits and promote tissue health and homeostasis. Immunoglobulin A (IgA) responses directly determine the composition of commensal species that colonize the intestinal tract but require substantial metabolic resources to fuel antibody production by tissue-resident plasma cells. Here, we demonstrate that IgA responses are subject to diurnal regulation over the course of a circadian day. Specifically, the magnitude of IgA secretion, as well as the transcriptome of intestinal IgA⁺ plasma cells, was found to exhibit rhythmicity. Oscillatory IgA responses were found to be entrained by time of feeding and were also found to be in part coordinated by

SUBMITTER: Penny HA 

PROVIDER: S-EPMC7613662 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature