Multifaceted role of chemokines in solid tumors: From biology to therapy.

ABSTRACT: Chemokines are small secretory chemotactic cytokines that control the directed migration of immune cells. Chemokines are involved in both anti-and pro-tumorigenic immune responses. Accumulating evidence suggests that the balance between these responses is influenced by several factors such as the stage of tumorigenesis, immune cell activation, recruitment of immune activating or immunosuppressive cells in the tumor microenvironment (TME), and chemokine receptor expression on effector and regulatory target cells. Cancer cells engage in a complex network with their TME components via several factors including growth factors, cytokines and chemokines that are critical for the growth of primary tumor and metastasis. However, chemokines show a multifaceted role in tumor progression including ma

SUBMITTER: Raza S 

PROVIDER: S-EPMC7613720 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature