Associations of maternal angiogenic factors during pregnancy with childhood carotid intima-media thickness and blood pressure.

ABSTRACT:

Background and aims

Reduced maternal placental growth factor (PlGF) and higher soluble fms-like tyrosine kinase (sFlt-1) concentrations in pregnancy may have persistent effects on offspring vasculature. We hypothesized that suboptimal maternal angiogenic factors in pregnancy may adversely affect fetal vascular development, leading to an increased risk of adverse atheriosclerotic adaptations and higher blood pressure in offspring.

Methods

In a population-based prospective cohort among 4565 women and their offspring, we examined the associations of maternal serum PlGF and sFlt-1 concentrations in the first half of pregnancy with offspring vascular development. We measured childhood blood pressure and obtained childhood carotid intima media thickness and carotid distensibility

SUBMITTER: Bongers-Karmaoui MN 

PROVIDER: S-EPMC7613754 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature