Vitamin B12, folate and homocysteine concentrations during pregnancy and early signs of atherosclerosis at school-age.

ABSTRACT:

Background & aims

Suboptimal circulating vitamin B12, folate and homocysteine concentrations during fetal life seem to be associated with cardiometabolic health at school-age. We examined whether fetal exposure to lower circulating vitamin B12 and folate concentrations and higher circulating homocysteine concentrations is also associated with early signs of atherosclerosis at school-age.

Methods

This study among 3826 school-age children and their mothers was embedded in the Generation R Study, a population-based prospective cohort study from early pregnancy onwards. We examined the associations of early-pregnancy and cord blood serum total and active B12 and plasma folate and homocysteine concentrations with common carotid artery intima-media thickness and distensibility in

SUBMITTER: Monasso GS 

PROVIDER: S-EPMC7613758 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature