Epigenetics and ADHD: Reflections on Current Knowledge, Research Priorities and Translational Potential.

ABSTRACT: Attention-deficit/hyperactivity disorder (ADHD) is a common and debilitating neurodevelopmental disorder influenced by both genetic and environmental factors, typically identified in the school-age years but hypothesized to have developmental origins beginning in utero. To improve current strategies for prediction, prevention and treatment, a central challenge is to delineate how, at a molecular level, genetic and environmental influences jointly shape ADHD risk, phenotypic presentation, and developmental course. Epigenetic processes that regulate gene expression, such as DNA methylation, have emerged as a promising molecular system in the search for both biomarkers and mechanisms to address this challenge. In this Current Opinion, we discuss the relevance of epigenetics (specifically DNA

SUBMITTER: Cecil CAM 

PROVIDER: S-EPMC7613776 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature