Enantiodivergent epoxidation of alkenes with a photoswitchable phosphate manganese-salen complex

ABSTRACT: The development of enantiodivergent catalysts capable of preparing both enantiomeric products from one substrate in a controlled fashion is challenging. Introducing a switching function into the catalyst can address this challenge, allowing the chiral reaction environment to reversibly change during catalysis. Here we report a photoswitchable phosphate ligand, derived from 2,2’-biphenol, which axially coordinates as the counter ion to an achiral manganese(III) salen catalyst, providing the latter with the ability to switch stereoselectivity in the epoxidation of alkenes. The enantiomers of the chiral ligand exist as a pair of pseudo-enantiomers, which can be interconverted by irradiation with light of different wavelengths. The opposite axial chirality of these pseudo-enantiomers is effici

SUBMITTER: Chen X 

PROVIDER: S-EPMC7613796 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature