The Transcriptome of <i>Schistosoma mansoni</i> Developing Eggs Reveals Key Mediators in Pathogenesis and Life Cycle Propagation.

ABSTRACT: Schistosomiasis, the most important helminthic disease of humanity, is caused by infection with parasitic flatworms of the genus Schistosoma. The disease is driven by parasite eggs becoming trapped in host tissues, followed by inflammation and granuloma formation. Despite abundant transcriptome data for most developmental stages of the three main human-infective schistosome species-Schistosoma mansoni, S. japonicum and S. haematobium-the transcriptomic profiles of developing eggs remain under unexplored. In this study, we performed RNAseq of S. mansoni eggs laid in vitro during early and late embryogenesis, days 1-3 and 3-6 post-oviposition, respectively. Analysis of the transcriptomes identified hundreds of up-regulated genes during the later stage, incl

SUBMITTER: Lu Z 

PROVIDER: S-EPMC7613829 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature