Genetically predicted circulating vitamin C in relation to cardiovascular disease.

ABSTRACT:

Aim

We conducted a two-sample Mendelian randomization (MR) study to assess the associations of genetically predicted circulating vitamin C levels with cardiovascular diseases (CVDs).

Methods and results

Ten lead single-nucleotide polymorphisms associated with plasma vitamin C levels at the genome-wide significance level were used as instrumental variables. Summary-level data for 15 CVDs were obtained from corresponding genetic consortia, the UK Biobank study, and the FinnGen consortium. The inverse-variance-weighted method was the primary analysis method, supplemented by the weighted median and MR-Egger methods. Estimates for each CVD from different sources were combined. Genetically predicted vitamin C levels were not associated with any CVD after accounting for multiple te

SUBMITTER: Yuan S 

PROVIDER: S-EPMC7613857 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature