Transcriptional comparison of testicular adrenal rest tumors with fetal and adult tissues.

ABSTRACT:

Background

Testicular adrenal rest tumors (TART) are a common complication of unknown cellular origin in patients with congenital adrenal hyperplasia (CAH). These benign tumors have both adrenal and testicular characteristics and are hypothesized to either derive from cells of adrenal origin from the fetal adrenogonadal primordium or by atypical differentiation of adult Leydig-progenitor cells.

Objective

This study aims to unravel the identity and etiology of TART.

Methods

Co-expression of adrenal-specific CYP11B1 and Leydig cell-specific HSD17B3 in TART was studied using immunohistochemistry. We studied the possibility of TART being derived from atypical differentiation of adult Leydig-progenitor cells by the quantification of adrenal-specific enzyme expression upon

SUBMITTER: Schroder MAM 

PROVIDER: S-EPMC7613903 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature