Retroviruses integrate into a shared, non-palindromic DNA motif.

ABSTRACT: Many DNA-binding factors, such as transcription factors, form oligomeric complexes with structural symmetry that bind to palindromic DNA sequences¹. Palindromic consensus nucleotide sequences are also found at the genomic integration sites of retroviruses^2-6 and other transposable elements^7-9, and it has been suggested that this palindromic consensus arises as a consequence of the structural symmetry in the integrase complex^2,3. However, we show here that the palindromic consensus sequence is not present in individual integration sites of human T-cell lymphotropic virus type 1 (HTLV-1) and human immunodeficiency virus type 1 (HIV-1), but arises in the population average as a consequence of the existence of a non-palindromic nucleotide motif that

SUBMITTER: Kirk PD 

PROVIDER: S-EPMC7613964 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature