YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS-STING.

ABSTRACT: Ageing is intimately connected to the induction of cell senescence^1,2, but why this is so remains poorly understood. A key challenge is the identification of pathways that normally suppress senescence, are lost during ageing and are functionally relevant to oppose ageing³. Here we connected the structural and functional decline of ageing tissues to attenuated function of the master effectors of cellular mechanosignalling YAP and TAZ. YAP/TAZ activity declines during physiological ageing in stromal cells, and mimicking such decline through genetic inactivation of YAP/TAZ in these cells leads to accelerated ageing. Conversely, sustaining YAP function rejuvenates old cells and opposes the emergence of ageing-related traits associated with either physiological ageing or a

SUBMITTER: Sladitschek-Martens HL 

PROVIDER: S-EPMC7613988 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature