Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals.

ABSTRACT: Ferroptosis is a type of cell death caused by radical-driven lipid peroxidation, leading to membrane damage and rupture. Here we show that enzymatically produced sulfane sulfur (S⁰) species, specifically hydropersulfides, scavenge endogenously generated free radicals and, thereby, suppress lipid peroxidation and ferroptosis. By providing sulfur for S⁰ biosynthesis, cysteine can support ferroptosis resistance independently of the canonical GPX4 pathway. Our results further suggest that hydropersulfides terminate radical chain reactions through the formation and self-recombination of perthiyl radicals. The autocatalytic regeneration of hydropersulfides may explain why low micromolar concentrations of persulfides suffice to produce potent cytoprotective effects on a back

SUBMITTER: Barayeu U 

PROVIDER: S-EPMC7613997 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature