Heterogeneous stochastic bifurcations explain intrinsic oscillatory patterns in entorhinal cortical stellate cells.

ABSTRACT: Stellate cells (SC) in the medial entorhinal cortex manifest intrinsic membrane potential oscillatory patterns. Although different theoretical frameworks have been proposed to explain these patterns, a robust unifying framework that jointly accounts for intrinsic heterogeneities and stochasticity is missing. Here, we first performed in vitro patch-clamp electrophysiological recordings from rat SCs and found pronounced cell-to-cell variability in their characteristic physiological properties, including peri-threshold oscillatory patterns. We demonstrate that noise introduced into two independent populations (endowed with deterministic or stochastic ion-channel gating kinetics) of heterogeneous biophysical models yielded activity patterns that were qualitatively similar to electrophysiologic

SUBMITTER: Mittal D 

PROVIDER: S-EPMC7613999 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature