An MR fingerprinting approach for quantitative inhomogeneous magnetization transfer imaging.

ABSTRACT:

Purpose

Magnetization transfer (MT) and inhomogeneous MT (ihMT) contrasts are used in MRI to provide information about macromolecular tissue content. In particular, MT is sensitive to macromolecules, and ihMT appears to be specific to myelinated tissue. This study proposes a technique to characterize MT and ihMT properties from a single acquisition, producing both semiquantitative contrast ratios and quantitative parameter maps.

Theory and methods

Building on previous work that uses multiband RF pulses to efficiently generate ihMT contrast, we propose a cyclic steady-state approach that cycles between multiband and single-band pulses to boost the achieved contrast. Resultant time-variable signals are reminiscent of an MR fingerprinting acquisition, except that the signal flu

SUBMITTER: West DJ 

PROVIDER: S-EPMC7614010 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature