Learning from BMPs and their biophysical extracellular matrix microenvironment for biomaterial design.

ABSTRACT: It is nowadays well-accepted that the extracellular matrix (ECM) is not a simple reservoir for growth factors but is an organization center of their biological activity. In this review, we focus on the ability of the ECM to regulate the biological activity of BMPs. In particular, we survey the role of the ECM components, notably the glycosaminoglycans and fibrillary ECM proteins, which can be promoters or repressors of the biological activities mediated by the BMPs. We examine how a process called mechano-transduction induced by the ECM can affect BMP signaling, including BMP internalization by the cells. We also focus on the spatio-temporal regulation of the BMPs, including their release from the ECM, which enables to modulate their spatial localization as well as their local concentratio

SUBMITTER: Migliorini E 

PROVIDER: S-EPMC7614069 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature