Identification of aceNKPs, a committed common progenitor population of the ILC1 and NK cell continuum.

ABSTRACT: The development of innate lymphoid cell (ILC) transcription factor reporter mice has shown a previously unexpected complexity in ILC hematopoiesis. Using novel polychromic mice to achieve higher phenotypic resolution, we have characterized bone marrow progenitors that are committed to the group 1 ILC lineage. These common ILC1/NK cell progenitors (ILC1/NKP), which we call "aceNKPs", are defined as lineage^-Id2⁺IL-7Rα⁺CD25^-α4β7^-NKG2A/C/E⁺Bcl11b^-. In vitro, aceNKPs differentiate into group 1 ILCs, including NK-like cells that express Eomes without the requirement for IL-15, and produce IFN-γ and perforin upon IL-15 stimulation. Following reconstitution of Rag2^-/-Il2rg^-/- hosts, aceNKPs gi

SUBMITTER: Rodriguez-Rodriguez N 

PROVIDER: S-EPMC7614094 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature