Relationship Between Ascending Thoracic Aortic Diameter and Blood Pressure: A Mendelian Randomization Study.

ABSTRACT:

Background

Observational studies identified elevated blood pressure (BP) as a strong risk factor for thoracic aortic dilation, and BP reduction is the primary medical intervention recommended to prevent progression of aortic aneurysms. However, although BP may impact aortic dilation, aortic size may also impact BP. The causal relationship between BP and thoracic aortic size has not been reliably established.

Methods

Genome-wide association studies summary statistics were obtained for BP and ascending thoracic aortic diameter (AscAoD). Causal effects of BP on AscAoD were estimated using 2-sample Mendelian randomization using a range of pleiotropy-robust methods.

Results

Genetically predicted increased systolic BP, diastolic BP, and mean arterial pressure all significan

SUBMITTER: DePaolo J 

PROVIDER: S-EPMC7614108 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature