A Comprehensive Study of the Effect on Colorectal Cancer Survival of Common Germline Genetic Variation Previously Linked with Cancer Prognosis.

ABSTRACT:

Background

Germline genetic variants may influence pathways of tumor progression common to multiple cancer types. Here, we investigated the association between survival after colorectal cancer diagnosis and 128 common genetic variants previously associated with prognosis in genome-wide association studies in different cancer types.

Methods

We studied survival outcomes in a large well-documented, prospective, population-based cohort (5,675 patients with colorectal cancer) with up to 20 years' follow-up.

Results

None of the 128 variants were significantly associated with overall or colorectal cancer-specific survival (P < 5 × 10^-4, Bonferroni-corrected threshold). We observed suggestive evidence (P < 0.05) for eight variants (rs17026425, rs17057

SUBMITTER: He Y 

PROVIDER: S-EPMC7614160 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature