Mapping gene by early life stress interactions on child subcortical brain structures: A genome-wide prospective study.

ABSTRACT:

Background

Although it is well-established that both genetics and the environment influence brain development, they are typically examined separately. Here, we aimed to prospectively investigate the interactive effects of genetic variants-from a genome-wide approach-and early life stress (ELS) on child subcortical brain structures, and their association with subsequent mental health problems.

Method

Primary analyses were conducted using data from the Generation R Study (N = 2257), including genotype and cumulative prenatal and postnatal ELS scores (encompassing life events, contextual risk, parental risk, interpersonal risk, direct victimisation). Neuroimaging data were collected at age 10 years, including intracranial and subcortical brain volumes (accumbens, amygdal

SUBMITTER: Bolhuis K 

PROVIDER: S-EPMC7614163 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature