Patient stratification for determining optimal second-line and third-line therapy for type 2 diabetes: the TriMaster study.

ABSTRACT: Precision medicine aims to treat an individual based on their clinical characteristics. A differential drug response, critical to using these features for therapy selection, has never been examined directly in type 2 diabetes. In this study, we tested two hypotheses: (1) individuals with body mass index (BMI) > 30 kg/m², compared to BMI ≤ 30 kg/m², have greater glucose lowering with thiazolidinediones than with DPP4 inhibitors, and (2) individuals with estimated glomerular filtration rate (eGFR) 60-90 ml/min/1.73 m², compared to eGFR >90 ml/min/1.73 m², have greater glucose lowering with DPP4 inhibitors than with SGLT2 inhibitors. The primary endpoint for both hypotheses was the achieved HbA1c difference between strata for the two drugs. In total

SUBMITTER: Shields BM 

PROVIDER: S-EPMC7614216 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature