Can polygenic risk scores contribute to cost-effective cancer screening? A systematic review.

ABSTRACT:

Purpose

Polygenic risk influences susceptibility to cancer. We assessed whether polygenic risk scores could be used in conjunction with other predictors of future disease status in cost-effective risk-stratified screening for cancer.

Methods

We undertook a systematic review of papers that evaluated the cost-effectiveness of screening interventions informed by polygenic risk scores compared with more conventional screening modalities. We included papers reporting cost-effectiveness outcomes with no restriction on type of cancer or form of polygenic risk modeled. We evaluated studies using the Quality of Health Economic Studies checklist.

Results

A total of 10 studies were included in the review, which investigated 3 cancers: prostate (n = 5), colorectal (n = 3), and br

SUBMITTER: Dixon P 

PROVIDER: S-EPMC7614235 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature