Empirical Antimicrobial Therapy of Neonates with Necrotizing Enterocolitis: A Systematic Review.

ABSTRACT:

Objective

Necrotizing enterocolitis (NEC) is an inflammatory disease of the gastrointestinal tract characterized by ischemic necrosis of the intestinal mucosa, mostly affecting premature neonates. Management of NEC includes medical care and surgical approaches, with supportive care and empirical antibiotic therapy recommended to avoid any disease progression. However, there is still no clear evidence-based consensus on empiric antibiotic strategies or surgical timing. This study was aimed to review the available evidence on the effectiveness and safety of different antibiotic regimens for NEC.

Study design

MEDLINE, EMBASE, Cochrane CENTRAL, and CINAHL databases were systematically searched through May 31, 2020. Randomized controlled trials (RCTs) and nonrandomized interventi

SUBMITTER: Dona D 

PROVIDER: S-EPMC7614399 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature