Structural snapshot of a β-arrestin-biased receptor.
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ABSTRACT:
SUBMITTER: Sarma P
PROVIDER: S-EPMC7614537 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
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Structural snapshot of a β-arrestin-biased receptor.
Sarma Parishmita P Banerjee Ramanuj R Shukla Arun K AK
Trends in pharmacological sciences 20220831 1
Atypical chemokine receptor subtype 3 (ACKR3), a chemokine receptor, couples selectively to β-arrestins (βarrs) but not to G proteins despite having seven transmembrane (7TM) helix architecture. Yen et al. present cryogenic-electron microscopy (cryo-EM) structures of agonist-bound ACKR3, elucidating a distinct chemokine-binding mechanism, and offering a structural template to probe the transducer-coupling bias at this receptor. ...[more]
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