Novel Application of Behavioral Assays Allows Dissociation of Joint Pathology from Systemic Extra-Articular Alterations Induced by Inflammatory Arthritis.

ABSTRACT:

Introduction

Although rheumatoid arthritis (RA) is a disease of articular joints, patients often suffer from co-morbid neuropsychiatric changes, such as anxiety, that may reflect links between heightened systemic inflammation and abnormal regulation of the hypothalamic-pituitary-adrenal (HPA) axis. Here, we apply behavioral neuroscience methods to assess the impact of antigen-induced arthritis (AIA) on behavioral performance in wild type (WT) and interleukin-10 deficient (Il10^-/-) mice. Our aim was to identify limb-specific motor impairments, as well as neuropsychological responses to inflammatory arthritis.

Methods

Behavioral testing was performed longitudinally in WT and Il10^-/- mice before and after the induction of arthritic joint path

SUBMITTER: Harvey AK 

PROVIDER: S-EPMC7614560 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature