Obesity and Kidney Function: A Two-Sample Mendelian Randomization Study.

ABSTRACT:

Background

Obesity and type 2 diabetes (T2D) are correlated risk factors for chronic kidney disease (CKD).

Methods

Using summary data from GIANT (Genetic Investigation of Anthropometric Traits), DIAGRAM (DIAbetes Genetics Replication And Meta-analysis), and CKDGen (CKD Genetics), we examined causality and directionality of the association between obesity and kidney function. Bidirectional 2-sample Mendelian randomization (MR) estimated the total causal effects of body mass index (BMI) and waist-to-hip ratio (WHR) on kidney function, and vice versa. Effects of adverse obesity and T2D were examined by stratifying BMI variants by their association with WHR and T2D. Multivariable MR estimated the direct causal effects of BMI and WHR on kidney function. The inverse variance weigh

SUBMITTER: Kjaergaard AD 

PROVIDER: S-EPMC7614591 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature