Impact of tolerance to fluconazole on treatment response in Candida albicans bloodstream infection.

ABSTRACT:

Background

Treatment of Candida albicans bloodstream infection with fluconazole is associated with significant mortality despite in vitro susceptibility to the drug.

Objectives

We sought to determine whether tolerance to fluconazole is predictive of treatment failure.

Methods

We reviewed patients with monomicrobial C albicans bloodstream infection who received primary monotherapy with fluconazole. Tolerance to fluconazole, defined as the fraction of growth above the MIC, was quantified using the disc diffusion assay and digital image analyses. Survival analyses were performed with host and treatment factors as predictive variables.

Results

Among 44 patients included in the study, all-cause mortality was 29.5% at 30 days and 43.1% at 12 weeks. Forty-one isolates

SUBMITTER: Levinson T 

PROVIDER: S-EPMC7614594 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature