Injecting drug use predicts active tuberculosis in a national cohort of people living with HIV.

ABSTRACT:

Objectives

Tuberculosis (TB) is common in people living with HIV, leading to worse clinical outcomes including increased mortality. We investigated risk factors for developing TB following HIV diagnosis.

Design

Adults aged at least 15 years first presenting to health services for HIV care in England, Wales or Northern Ireland from 2000 to 2014 were identified from national HIV surveillance data and linked to TB surveillance data.

Methods

We calculated incidence rates for TB occurring more than 91 days after HIV diagnosis and investigated risk factors using multivariable Poisson regression.

Results

A total of 95 003 adults diagnosed with HIV were followed for 635 591 person-years; overall incidence of TB was 344 per 100 000 person-years (95% confidence interval

SUBMITTER: Winter JR 

PROVIDER: S-EPMC7614667 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature