QT-GWAS: A novel method for unveiling biosynthetic loci affecting qualitative metabolic traits.

ABSTRACT: Although the plant kingdom provides an enormous diversity of metabolites with potentially beneficial applications for humankind, a large fraction of these metabolites and their biosynthetic pathways remain unknown. Resolving metabolite structures and their biosynthetic pathways is key to gaining biological understanding and to allow metabolic engineering. In order to retrieve novel biosynthetic genes involved in specialized metabolism, we developed a novel untargeted method designated as qualitative trait GWAS (QT-GWAS) that subjects qualitative metabolic traits to a genome-wide association study, while the conventional metabolite GWAS (mGWAS) mainly considers the quantitative variation of metabolites. As a proof of the validity of QT-GWAS, 23 and 15 of the retrieved associations identifie

SUBMITTER: Brouckaert M 

PROVIDER: S-EPMC7614782 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature