Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor.

ABSTRACT: Homologous recombination is a fundamental process of life. It is required for the protection and restart of broken replication forks, the repair of chromosome breaks and the exchange of genetic material during meiosis. Individuals with mutations in key recombination genes, such as BRCA2 (also known as FANCD1), or the RAD51 paralogues RAD51B, RAD51C (also known as FANCO), RAD51D, XRCC2 (also known as FANCU) and XRCC3, are predisposed to breast, ovarian and prostate cancers^1-10 and the cancer-prone syndrome Fanconi anaemia^11-13. The BRCA2 tumour suppressor protein-the product of BRCA2-is well characterized, but the cellular functions of the RAD51 paralogues remain unclear. Genetic knockouts display growth defects, reduced RAD51 focus formation, spontaneous chromosome ab

SUBMITTER: Greenhough LA 

PROVIDER: S-EPMC7614784 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature