Associations between vitamin D and autoimmune diseases: Mendelian randomization analysis.

ABSTRACT:

Objective

The VITAL trial of vitamin D supplementation suggested a possible protective effect for autoimmune diseases but uncertainties remain. We investigated potential causal effects of vitamin D on composite and individual autoimmune diseases using Mendelian randomization.

Methods

We used data from 332,984 participants of the UK Biobank of whom 23,089 had at least one autoimmune disease defined using ICD code and/or self-report. Diseases were further considered in mechanistic subgroups driven by "autoimmunity" (n = 12,774) or "autoinflammation" (n = 11,164), then individually. We selected variants within gene regions implicated in vitamin D biology to generate a weighted genetic score. We performed population-wide analysis using the ratio method, then examined non-linear

SUBMITTER: Zhao SS 

PROVIDER: S-EPMC7614794 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature