Synthetic lethal approaches to target cancers with loss of PTEN function.

ABSTRACT: Phosphatase and tensin homolog (PTEN) is a tumour suppressor gene and has a role in inhibiting the oncogenic AKT signalling pathway by dephosphorylating phosphatidylinositol 3,4,5-triphosphate (PIP₃) into phosphatidylinositol 4,5-bisphosphate (PIP₂). The function of PTEN is regulated by different mechanisms and inactive PTEN results in aggressive tumour phenotype and tumorigenesis. Identifying targeted therapies for inactive tumour suppressor genes such as PTEN has been challenging as it is difficult to restore the tumour suppressor functions. Therefore, focusing on the downstream signalling pathways to discover a targeted therapy for inactive tumour suppressor genes has highlighted the importance of synthetic lethality studies. This review focuse

SUBMITTER: Ertay A 

PROVIDER: S-EPMC7614861 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature