Oncogenic Ras deregulates cell-substrate interactions during mitotic rounding and respreading to alter cell division orientation.

ABSTRACT: Oncogenic Ras has been shown to change the way cancer cells divide by increasing the forces generated during mitotic rounding. In this way, Ras^V12 enables cancer cells to divide across a wider range of mechanical environments than normal cells. Here, we identify a further role for oncogenic Ras-ERK signaling in division by showing that Ras^V12 expression alters the shape, division orientation, and respreading dynamics of cells as they exit mitosis. Many of these effects appear to result from the impact of Ras^V12 signaling on actomyosin contractility, because Ras^V12 induces the severing of retraction fibers that normally guide spindle positioning and provide a memory of the interphase cell shape. In support of this idea, the Ras^V12 pheno

SUBMITTER: Ganguli S 

PROVIDER: S-EPMC7614879 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature