Super-Resolution Microscopy of the Synaptonemal Complex within the Caenorhabditis elegans Germline.

ABSTRACT: During meiosis, homologous chromosomes must recognize and adhere to one another to allow for their correct segregation. One of the key events that secures the interaction of homologous chromosomes is the assembly of the synaptonemal complex (SC) in meiotic prophase I. Even though there is little sequence homology between protein components within the SC among different species, the general structure of the SC has been highly conserved during evolution. In electron micrographs, the SC appears as a tripartite, ladder-like structure composed of lateral elements or axes, transverse filaments, and a central element. However, precisely identifying the localization of individual components within the complex by electron microscopy to determine the molecular structure of the SC remains challenging

SUBMITTER: Cavka I 

PROVIDER: S-EPMC7614930 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature