TRIM22 genotype is not associated with markers of disease progression in children with HIV-1 infection.

ABSTRACT:

Objective

Untreated perinatal HIV-1 infection is often associated with rapid disease progression in children with HIV (CWH), characterized by high viral loads and early mortality. TRIM22 is a host restriction factor, which directly inhibits HIV-1 transcription, and its genotype variation is associated with disease progression in adults. We tested the hypothesis that TRIM22 genotype is associated with disease progression in CWH.

Design

ART-naive CWH, aged 6-16 years, were recruited from primary care clinics in Harare, Zimbabwe. We performed a candidate gene association study of TRIM22 genotype and haplotypes with markers of disease progression and indicators of advanced disease.

Methods

TRIM22 exons three and four were sequenced by Sanger sequencing and single nucleoti

SUBMITTER: Boswell MT 

PROVIDER: S-EPMC7614957 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature