The cell-assembled extracellular matrix: A focus on the storage stability and terminal sterilization of this human "bio" material.

ABSTRACT: The Cell-Assembled extracellular Matrix (CAM) is an attractive biomaterial because it provided the backbone of vascular grafts that were successfully implanted in patients, and because it can now be assembled in "human textiles". For future clinical development, it is important to consider key manufacturing questions. In this study, the impact of various storage conditions and sterilization methods were evaluated. After 1 year of dry frozen storage, no change in mechanical nor physicochemical properties were detected. However, storage at 4 °C and room temperature resulted in some mechanical changes, especially for dry CAM, but physicochemical changes were minor. Sterilization modified CAM mechanical and physicochemical properties marginally except for hydrated gamma treatment. All steriliz

SUBMITTER: Potart D 

PROVIDER: S-EPMC7614989 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature