Multivariate analyses of molecular genetic associations between childhood psychopathology and adult mood disorders and related traits.

ABSTRACT: Ubiquitous associations have been detected between different types of childhood psychopathology and polygenic risk scores based on adult psychiatric disorders and related adult outcomes, indicating that genetic factors partly explain the association between childhood psychopathology and adult outcomes. However, these analyses in general do not take into account the correlations between the adult trait and disorder polygenic risk scores. This study aimed to further clarify the influence of genetic factors on associations between childhood psychopathology and adult outcomes by accounting for these correlations. Using a multivariate multivariable regression, we analyzed associations of childhood attention-deficit/hyperactivity disorder (ADHD), internalizing, and social problems, with polygeni

SUBMITTER: Akingbuwa WA 

PROVIDER: S-EPMC7615008 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature