Mechanical constraints to cell-cycle progression in a pseudostratified epithelium.

ABSTRACT: As organs and tissues approach their normal size during development or regeneration, growth slows down, and cell proliferation progressively comes to a halt. Among the various processes suggested to contribute to growth termination,^1-10 mechanical feedback, perhaps via adherens junctions, has been suggested to play a role.^11-14 However, since adherens junctions are only present in a narrow plane of the subapical region, other structures are likely needed to sense mechanical stresses along the apical-basal (A-B) axis, especially in a thick pseudostratified epithelium. This could be achieved by nuclei, which have been implicated in mechanotransduction in tissue culture.¹⁵ In addition, mechanical constraints imposed by nuclear crowding and spatial confinement

SUBMITTER: Hecht S 

PROVIDER: S-EPMC7615048 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature