A recombinant commensal bacteria elicits heterologous antigen-specific immune responses during pharyngeal carriage.

ABSTRACT: The human nasopharynx contains a stable microbial ecosystem of commensal and potentially pathogenic bacteria, which can elicit protective primary and secondary immune responses. Experimental intranasal infection of human adults with the commensal Neisseria lactamica produced safe, sustained pharyngeal colonization. This has potential utility as a vehicle for sustained release of antigen to the human mucosa, but commensals in general are thought to be immunologically tolerated. Here, we show that engineered N. lactamica, chromosomally transformed to express a heterologous vaccine antigen, safely induces systemic, antigen-specific immune responses during carriage in humans. When the N. lactamica expressing the meningococcal antigen Neisseria Adhesin A (NadA) was inoculat

SUBMITTER: Laver JR 

PROVIDER: S-EPMC7615050 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature