Associations of alcohol intake with subclinical carotid atherosclerosis in 22,000 Chinese adults.

ABSTRACT:

Background and aims

We investigated the causal relevance of alcohol intake with measures of carotid artery thickness and atherosclerosis in Chinese adults.

Methods

The study included 22,384 adults from the China Kadoorie Biobank, with self-reported alcohol use at baseline and resurvey, carotid artery ultrasound measurements, and genotyping data for ALDH2-rs671 and ADH1B-rs1229984. Associations of carotid intima media thickness (cIMT), any carotid plaque, and total plaque burden (derived from plaque number and size) with self-reported (conventional analyses) and genotype-predicted mean alcohol intake (Mendelian randomization) were assessed using linear and logistic regression models.

Results

Overall 34.2% men and 2.1% women drank alcohol regularly at baseline. Mean cIM

SUBMITTER: Zhou T 

PROVIDER: S-EPMC7615083 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature