The clinical impact of observer variability in lung nodule classification in children with Wilms tumour.

ABSTRACT:

Objectives

To investigate the extent to which observer variability of computed tomography (CT) lung nodule assessment may affect clinical treatment stratification in Wilms tumour (WT) patients, according to the recent Société Internationale d'Oncologie Pédiatrique Renal Tumour Study Group (SIOP-RTSG) UMBRELLA protocol.

Methods

I: CT thoraces of children with WT submitted for central review were used to estimate size distribution of lung metastases. II: Scans were selected for blinded review by five radiologists to determine intra- and inter-observer variability. They assessed identical scans on two occasions 6 months apart. III: Monte Carlo simulation (MCMC) was used to predict the clinical impact of observer variation when applying the UMBRELLA protocol size criteria.

Re

SUBMITTER: Brok JS 

PROVIDER: S-EPMC7615195 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature